Which of the following pathologies affects the skeletal system?

Gout is a pathology that specifically affects the skeletal system, particularly the joints. It is a form of inflammatory arthritis caused by an excess of uric acid in the blood, which can lead to the formation of sharp crystals in joints, most commonly in the big toe. This condition results in painful and swollen joints, indicating a direct impact on the skeletal system through inflammation and damage.

In contrast, the other conditions listed do not primarily affect the skeletal system. Fibromyalgia is characterized by widespread musculoskeletal pain, fatigue, and tenderness, but it is more related to the nervous system processing pain rather than structural issues within the skeletal system. Myofascial Pain Syndrome involves pain and discomfort in muscle tissue and is primarily a soft tissue issue, not affecting bones or joints directly. Edema refers to the accumulation of fluid in tissues and is often related to vascular problems, further illustrating that it does not involve the skeletal structure itself.