Which muscular pathology is characterized by widespread pain and fatigue?

Myofascial Pain Syndrome is characterized by widespread pain and fatigue due to the presence of trigger points in muscle tissue. These trigger points are hyperirritable areas that may lead to localized muscle pain as well as referred pain in other areas of the body. One of the hallmarks of this condition is the persistent ache and the sensation of fatigue that often accompanies it, making it difficult for individuals to engage in normal daily activities.

In contrast, muscular dystrophy primarily involves progressive weakness and degeneration of muscle fibers, rather than widespread pain and fatigue. Rheumatoid arthritis is mainly an autoimmune condition that affects joints, leading to pain, swelling, and stiffness, but it does not typically present with the widespread muscle pain associated with Myofascial Pain Syndrome. Edema refers to swelling caused by fluid retention and does not directly relate to muscle pain or fatigue characteristics. Thus, Myofascial Pain Syndrome is the most fitting diagnosis for widespread pain and fatigue among the options provided.